In murine cecal ligation and puncture (CLP) sepsis models, these differences in gut microbial composition often correspond to significant increases in mortality and differences in immune phenotypes in splenic or Peyer’s patch lymphocytes; these differences in immune phenotypes could be rescued through co-housing mice with wild-type animals, which results in improved T cell responses against bacterial antigens and directed IgA production, showing the interplay between the microbiome and the host immune response to sepsis [18,36,37]. This evidence concerns the gene CD79A and Sepsis.