HIF1A and breast carcinoma: In an in vitro study of human umbilical vein endothelial cells, Dewangan et al. demonstrated that salinomycin, a monocarboxylic polyether ionophore obtained from Streptomyces albus, reduced angiogenesis of breast cancer cell progression through inhibiting the HIF-1α/vascular endothelial growth factor signaling axis [51].