PPARGC1A and serum lipopolysaccharide activity: The downregulation of succinate dehydrogenase (SDH, complex II), cytochrome-c oxidase (complex IV), mitochondrial cytochrome C (a marker of mitochondrial structure integrity), and PGC-1α (a regulator of muscle oxidative capacity) were observed in mice with endotoxemia subjected to VT = 10 mL/kg in contrast to those without endotoxemia subjected to VT = 10 mL/kg and nonventilated control mice (Figure 4).