HIF1A and serum lipopolysaccharide activity: The effects of MV on different parameters, including an increase in mitochondrial injury, autophagosomes, and light chain 3-II (LC3-II) expression (a marker of increased autophagosome production) and a decrease in P62 expression (a marker of increased autophagic flux), in mice with endotoxemia treated with VT = 10 mL/kg were substantially restored in HIF-1α-deficient mice (Figure 6).