Figure 5A,B illustrate prediction performance for the cell lines and drugs with the highest prediction accuracy. As shown in Figure 5A, three of the top four cell lines were from head and neck (including thyroid) cancer. Interestingly, three out of the top four drugs target the PI3K/mTOR signaling pathway, and the remaining one targets the related ERK/MAPK signaling pathway [28]. The gene discussed is MTOR; the disease is thyroid gland disorder.