In conclusion, reduced concentration of active TGF-β1 resulting in TGF-β1 decreased signaling in the frontal cortex of mouse brain may aggravate the deficiency of synaptophysin and synaptotagmin content in the membrane fraction, determining the efficiency of vesicle trafficking to the membrane, observed in the acute model of HE, but does not explain the mechanism of impaired protein distribution. Here, TGFB1 is linked to hereditary elliptocytosis.