PNPLA3 and metabolic dysfunction-associated steatohepatitis: One can speculate that this may be related to genetic variations in other genes that modulate PCSK9 function, including Anx A2 (see above), or in genes such as the patatin-like phospholipase domain-containing 3 (PNPLA3) gene, which is well-described to progress NASH [44,158].