Implicating PCSK9 to regulate LDL-R and CD36 levels in adipocytes of obese patients, increased LDL-R and CD36 expression in white adipose tissue of obese patients with low PCSK9 levels was identified, which correlated with an activation of the NLRP3 inflammasome, higher grade of systemic inflammation and a higher risk for type 2 diabetes [181]. This evidence concerns the gene PCSK9 and type 2 diabetes mellitus.