Furthermore, pharmacological stimulation of the class-III HDAC sirtuin 1 (SIRT1), and the AMP-activated kinase (AMPK) by resveratrol (RESV) has been shown to protect against motor neuron death and improve survival in the SOD1(G93A) ALS mice model [36]. The gene discussed is SIRT1; the disease is amyotrophic lateral sclerosis.