MECOM and myeloid leukemia: Analyses of patient samples as well as functional studies using in vitro and in vivo model systems have implicated EVI1, the major protein product of the MECOM locus, as an oncoprotein in myeloid leukemias and in various solid tumor entities [8,9,11,12,14,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,33,34].