The exact biological function of PSMA in PCa is still not wholly understood; however, its possible role as a carboxypeptidase (folate hydrolase) on poly-g-gluta-mated folates, as a peptidase on the acidic neuropeptide N-acetylaspartyl glutamate, in endocytosis transport function, and invasiveness have all been suggested [6,7]. Here, FOLH1 is linked to posterior cortical atrophy.