SGCB and congestive heart failure: Diminished sGC activation in response to NO has been documented in conditions of increased cardiovascular risk, such as hypercholesterolemia, diabetes, and polycystic ovarian syndrome [15,30,31,32,33], as well as in a number of cardiovascular disease states, including ACS, CHF, aortic valve stenosis, and newly diagnosed AF [11,12,13,34,35,36].