INS and diabetes mellitus: Interestingly, while the overexpression of miR-7 in transgenic mouse β-cells causes diabetes due to impaired insulin secretion [50], overexpression of ciRS-7 leads to increased insulin secretion by islet cells by upregulating miR-7 target gene expressions, such as Myrip (myosin VIIA and Rab-interacting protein) [49].