Further silencing of circRNA_002581 significantly attenuated lipid droplet accumulation, eliminated liver damage, as evidenced by decreased levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), proinflammatory cytokines, apoptosis, and H2O2, and increased ATP levels in both mouse and cellular models of NASH [78]. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.