A downregulation of the hepcidin expression (up to 10 times in the severe HF group as compared to the controls) (Figure 5D) was strongly associated with HF development (R = −0,62, p = 0.0002), and ALT/AST ratio (R = −0,62, p = 0.0005) as well as with hepatomegaly PRA and aldosterone (Supplementary Table S3). This evidence concerns the gene GPT and hydrops fetalis.