In pigs with moderate HF, few preserved hepatocytes cords inside the centrilobular congestion areas showed very strong positive ferritin (FTL and FTH) staining as well as granular deposits (hemosiderin) (Figure 3A,B), while in severe HF, multiple irregular ferritin granular deposits within centrilobular regions were found (Figure 3A,C). This evidence concerns the gene FTL and hydrops fetalis.