Interestingly, in PD, a decrease in N-acetylaspartate level has been found [53,54,55,56,57,58], and the stimulation of the dopamine D1 receptor through an agonist could increase the expression of Nat8L, i.e., the enzyme responsible for N-acetylaspartate biosynthesis in mammals. Here, DRD1 is linked to Parkinson disease.