For instance, DNA methylation (including TET2, DNMT3A, and IDH1/2) or chromatin structure (contains ASXL1 and EZH2) and accessory mutations in the regulators are proposed to affect MPN specific phenotypes [63,97,98], promote progression, and induce phenotypic switching. The gene discussed is DNMT3A; the disease is myeloproliferative neoplasm.