CD40LG and infection: The Neonatal Intensive Care Unit (NICU) group is composed of premature babies and newborns with an increased risk of infections due to humoral immunodeficiency (decreased IgA, IgG, and IgM), decreased chemotaxis, low bone marrow reserve, decreased bowel movements, low acid concentration in the stomach, increased skin pH and permeability, as well as a lack of a proper composition of the microbiome [7].