Variants in CSMD1 have been associated with deleterious effects across a number of neurological and neuropsychiatric phenotypes (see the Supplementary, Table S1): autism [98], bipolar disorder [99], Alzheimer’s disease [100], Parkinson’s disease [101] and schizophrenia [102,103]. This evidence concerns the gene CSMD1 and early-onset autosomal dominant Alzheimer disease.