Given that the metabolic function modulator FOXO1 transcription factor induces the mir-506~514 cluster [83,84], and that impaired function of FOXO1 has been linked with GrCT development in mice [85], Chang et al. speculated that the mir-506~514 cluster and its relationship with FOXO1 may play a role in GrCT development [78]. The gene discussed is FOXO1; the disease is granulosa cell tumor.