SESN1 and sarcopenia: For example, despite the general awareness of sestrin-1’s role in aging, to the best of the authors’ knowledge, only two works have studied its association with frailty or sarcopenia in humans, and this is the first to analyze sestrin-1 in people living in nursing homes and its association with physical function, physical activity, and dependence, as well as frailty following three different scales and indices.