MAPT and dementia: However, the current updated research involves analysing brain physiology and targeting amyloid plaques amyloid-beta neurofibrillary tangles, tau protein, astrocyte associated β-secretase, cholinergic neuron associated butyrylcholinesterase, cognitive function in medial temporal lobe cortex, secretase (presenilin I), central nerves system associated GPCR-target, and dopamine-2 receptor, etc., for Alzheimer and dementia treatment [128,129].