BAX and colon adenocarcinoma: In addition, Hosseini et al.’s study showed Nisin could suppress proliferation of SW48, HT29, and Caco2 cells by regulation of the metastatic genes in colorectal cancer cells [56] as well as Ahamdi et al.’s study showed that the bax / bcl-2 ratio in the colon adenocarcinoma cell line raised during treatment with Nisin due to activation of the apoptotic pathway [62].