That applies, for example, to a common variant (I148M) in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene that encodes a protein involved in the lipid metabolism [21], which influences the severity of steatosis, steatohepatitis, fibrosis, and HCC risk in NAFLD as well as in ALD [22]. Here, PNPLA3 is linked to hepatocellular carcinoma.