Preclinical RA (asymptomatic and early symptomatic autoimmunity) with increased levels of autoantibodies and inflammatory cytokines, chemokines, and C-reactive protein can progress to undifferentiated arthritis (early RA) and classifiable RA with expansion of the autoantibody profile, resulting in detectable RF and anti-CCP up to 10 years before clinical disease onset [4]. Here, CRP is linked to rheumatoid arthritis.