CTLA4 and metastatic melanoma: Melanoma V600K has been demonstrated to be significantly more aggressive and rapid in progression than melanoma V600E with inclusive or partial data in terms of OS and PFS after receiving either one of the principal therapies approved for unresectable/metastatic melanoma (immunotherapy (PD/PDL-1 agent, CTLA4 agent) or BRAFi ± MEKi).