Recently, the RELATIVITY-047 (relatlimab + nivolumab vs. single agent nivolumab) trial has demonstrated a strong advantage in PFS of the combination of anti-LAG3 + anti PD-1 on single agent anti PD-1, with an excellent toxicity profile, promising to be the future first line of treatment for metastatic melanoma. This evidence concerns the gene LAG3 and metastatic melanoma.