The aim of this study was to investigate whether fibroblasts derived from high MD breast tissue may be creating a favourable environment for tumour development through the expression of genes indicative of a CAF-like phenotype such as SMA, COX2, FGF5, TGFB3, WNT5, VIM, TNC, IL6 and IL8. The gene discussed is SMN1; the disease is neoplasm.