PROS1 and Cirrhosis: Liver dysfunction leads to the decreased synthesis of several hemostatic proteins, procoagulants (prothrombin, factor V, and X) and anticoagulant factors (protein C, protein S, and antithrombin), resulting in a reduction in the plasma levels of most of these coagulation pathway components, generating a rebalance of the hemostatic system in patients with cirrhosis [29].