F2 and Cirrhosis: Additionally, the prevalence of the underlying acquired (myeloproliferative neoplasms, polycythemia vera), or inherited (protein C and protein S deficiencies, mutations in prothrombin (G20210A), factor V Leiden, etc.), prothrombotic diseases is very low in patients with cirrhosis [26,41], further suggesting the non-predominant role of hypercoagulability in PVT development.