We also observed significant upregulation of ACE2, TMPRSS2, and Furin expression in the alveolar epithelium within the parenchyma of IPF (ACE2 median 1.95, rang 0.56–4.24; TMPRSS2 median 3.19, range 2.22–4.39; Furin median 3.68, range 1.79–4.35; (p < 0.001)) and LAM (ACE2 median 1.22, range 0.64–1.62; TMPRSS2 median 2.31, range 2.05–4.56; Furin median 2.27, range 1.48–2.87; (p < 0.01)) patients compared to HC (ACE2 median 0.44. This evidence concerns the gene TMPRSS2 and idiopathic pulmonary fibrosis.