Compared to HC lung tissue (ACE2 median 4.65, range 2.89–8.32; TMPRSS2 median 1.98, range 0.47–10.94; Furin median 5.43, range 0.98–13.84), ACE2, TMPRSS2, and Furin expression were significantly upregulated in the airway epithelium of SAs of IPF (ACE2 median 9.35, range 7.05–10.98; TMPRSS2 median 24.88, range 19.9–39.28; Furin median 21.35, range 18.6–33.3; (p < 0.01)) and LAM (ACE2 median 10.84, range 9.02–12.61; TMPRSS2 median 37.37, range 32.52–38.41; Furin median 26.21, range 19.01–30.67; (p < 0.001)) patients (Figure 3i–iii). Here, ACE2 is linked to idiopathic pulmonary fibrosis.