Analysis of GDF15 was performed as described above, with the data set comprised of a total of 105 POAG AH samples and 117 non-glaucoma cataract AH samples derived from gender- and age-matched, but not race-matched, patient populations (Table S4 describes the demography details for all of the POAG patients of this study). Here, GDF15 is linked to open-angle glaucoma.