However, when the subset of POAG patients was categorized into mild, moderate, and severe POAG subgroups based on the median deviation of visual field loss, we did not find a definitive correlation between the levels of AH or serum GDF15 and disease severity of glaucoma, although there was an increasing trend in GDF15 levels in AH and serum with an increasing disease severity of glaucoma. The gene discussed is GDF15; the disease is open-angle glaucoma.