The authors concluded that increased immune cell infiltration of T and B cells as well as higher levels of PD-L1 expression in AcCC in association with high-grade transformation, lymph node metastasis, and an unfavorable prognosis suggests a relevant interaction between tumor cells and immune cell infiltrates in a subset of AcCCs, and might represent a rationale for immune checkpoint inhibition [94]. The gene discussed is CD274; the disease is neoplasm.