Additionally, taurine administered in combination with delayed t-PA has been shown to profoundly prevent tPA-associated hemorrhage (6 h after the onset of ischemia), to reduce mortality rate at 3 days from 47% to 21%, to significantly improve the long-term outcome after stroke, and to reduce the 45-day mortality rate from 55% to 31% (following 7 days taurine administration). The gene discussed is PLAT; the disease is ischemia.