Independent of the increment in neural density noticed in the tumor environment, numerous pain modulating agents such as hydrogen ions, tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), prostaglandins, interleukin-1 (IL-1) and IL-6 are set free into the tumor vicinity, sensitizing and stimulating sensory fibers, possibly contributing to neuronal hyperexcitability and pain [1]. The gene discussed is TNF; the disease is neoplasm.