RNASE3 and cystic fibrosis: Using whole gut lavage, Smyth et al. first reported in 2000 that circulating concentrations of inflammatory markers, including interleukin (IL)-8, IL-1β, albumin, immunoglobulin (Ig) M, IgG, neutrophil elastase and eosinophil cationic protein (ECP), were elevated in people with CF compared to immunologically normal controls [32].