As Figure 1 shows, a semiquantitative assessment revealed: (i) weak granular cytoplasmic positivity, more intensive in cirrhosis for NTCP; (ii) weak cytoplasmic positivity with a granular distribution in cirrhotic rats and moderate in controls for BSEP; (iii) continuous and thin immunoreactivity for P-Gly, always along apical membrane, more intensive in controls; (iv) weak positivity for ASBT in both groups; (v) loss of intensity in treated rats and a more intensive positivity in controls for MRP4; (vi) diffuse apical membrane positivity, more intensive in the treated animals for osteopontin. The gene discussed is SPP1; the disease is Cirrhosis.