From a pathophysiologic point of view, after systematic review, among the 109 miRNAs of our endometriosis signature, only four miRNAs (miR-34c-5p, miR-19b-1-5p, miR-149-5p, and miR-378a-3p) have previously been reported in patients with endometriosis; 25 have not been reported previously, implying that further studies should be conducted to confirm their involvement in the pathophysiology of endometriosis; and the remaining 80 are known to be involved in various signaling pathways, such as PI3K/Akt, PTEN, Wnt/β-catenin, HIF1α/NF κB, and YAP/TAZ/EGFR, with potential therapeutic implications. The gene discussed is PTEN; the disease is endometriosis.