THPO and autoimmune thrombocytopenic purpura: In one patient with severe immune thrombocytopenia refractory to splenectomy, corticosteroids, rituximab, and thrombopoietin agonists, who developed vitiligo and kidney and node granulomatosis while receiving monthly injections of intravenous immunoglobulins, the kidney biopsy showed interstitial nephropathy with intense phospho-STAT3 staining in lymphocytes and tubular cells (Figure 3).