Several studies have reported a differential effect on survival between microscopic invasion of perivesical tissue (pT3a) and macroscopic/extravesical mass (pT3b) [39,40], leading us to speculate that the CD36 positivity that we have observed in tumours invading the perivesical fat or peritoneum may reflect a metabolic change that enables cancer cells to obtain the energy and nutrients needed to confront metabolic stress and maintain tumour progression [41,42]. This evidence concerns the gene CD36 and neoplasm.