NPM1 and acute myeloid leukemia: Recent genomic-metabolic study on intracellular and biofluid metabolic AML samples allowed identifying a specific NPM1-mutated AML subgroup with high levels of serum choline, trimethylamine-N-oxide and leucine, characterized by common mutations of genes involved in DNA damage response and/or chromatid cohesion (NPM1/cohesion-mut) pathway.