PROM1 and osteosarcoma: As an example, an A15 Ap specific to CD133, a cancer stem cell (CSC) marker of osteosarcoma, was decorated on PLGA NPs (particle size ≈ 150 nm) for the targeted delivery of salinomycin, a polyether ionophore antibiotic with CSCs cytotoxic activity, to osteosarcoma CSCs.