Diverse target genes that played crucial roles in the synthesis of fatty acids and unsaturated fatty acids were annotated in the lncRNA transcripts, including FASN, LDLR, FDFT1, HMGCS1, ACSS2, SCARB1, SCD and 7 NAFLD-related genes, which further highlights the difference in fatty acid metabolism between the meat from pasture-fed or barn-fed black goats. This evidence concerns the gene HMGCS1 and metabolic dysfunction-associated steatotic liver disease.