The loss of DSC2 also resulted in a significant reduction in GATA6 expression at the endoderm stage, a marker vital for endoderm induction [6] that had been associated with the development of diabetes [49], pancreatic insufficiency, and congenital heart disease [50], and which plays a vital role in insulin production in adult β-cells [51]. The gene discussed is INS; the disease is exocrine pancreatic insufficiency.