Researchers were then able to show that loss of a single copy of the Cttnb1 gene (which encodes B-catenin, a Wnt pathway transducer) was able to prevent MDS in this same Apc-deficient mouse model, suggesting that this pathway is not only able to induce MDS when upregulated, but that suppression of the pathway can inhibit MDS development. The gene discussed is APC; the disease is myelodysplastic syndrome.