Pancreatic cancer patients lose an average of 13.7 kg, associated with the overexpression of 14 cachexia-inducing factor genes (CCL2, CXCL8, IL-1B, IL-6, IL-15, TNFSF10, TNFSF11, CSF1, CSF2, HGF, LIF, TGFA, PDGFB, and FGF2). Here, CXCL8 is linked to familial pancreatic carcinoma.