Given the multiple mechanisms of action known for lncRNAs, it is not surprising that the same lncRNAs may exert dual functions in cancer, acting as either tumor suppressors or oncogenes, depending on the cancer type (H19, BANCR, TINCR, MALAT, XIST) [44,54,55,56,57,58,59]. The gene discussed is XIST; the disease is cancer.