MTOR and neoplasm: Melanoma metastases are also characterized by a further increase of the tumor mutational burden and copy number alterations, mainly affecting MAPK, phosphoinositide-3-kinase (PI3K), protein-kinase-B (AKT), mammalian-target-of-rapamycin (mTOR), Janus-kinase (JAK), and signal-transducer-and-activator-of-transcription (STAT) pathways [5,9].