Furthermore, circ_0084043 expression positively regulates TRIB2 (a scaffold and atypical kinase that signals to canonical MAPKs and regulates the substrates’ ubiquitination) by sponging miR-429 Downregulation of TRIB2 upon circ_0084043 knockdown inhibits the Wnt/β-catenin signaling, thus suggesting a role of circ_0084043 in the phenotype switch in melanoma [149]. This evidence concerns the gene TRIB2 and melanoma.