Thus, expression of β-catenin, Cyclin D1, and Mmp7 remained high in adenomatous polyps compared to normal colon, and was unaffected by SPI3d or SPI treatment, although SPI increased cleaved PARP and Caspase–3 in Pirc colon tumors, indicative of apoptosis induction. The gene discussed is CCND1; the disease is colonic neoplasm.