Likewise, the dynamic changes of miR-21 were associated with an upregulation of myocardial injury markers including B-type Natriuretic Peptide (BNP) and A-type Natriuretic Peptide (ANP) but cardiac hypertrophy-related gene myosin heavy chain 7 (MYH7) dropped in late phase of rats subjected to AVS (Figure S1). This evidence concerns the gene NPPA and cardiac hypertrophy.