Prior studies demonstrate that neutralization of IFNγ or deficiency of IFNγ receptor confer protection against ALI and/or lethality induced by LPS [60,61,62], sepsis/systemic inflammatory response syndrome [62,63,64,65], hyperoxia/mechanical ventilation [66,67], and respiratory viral infection [68,69,70,71]. This evidence concerns the gene IFNG and Sepsis.