The signal transducers and activators of transcription (STAT) family is well known to mediate cell survival (stabilizing Bcl-2 and Survivin), proliferation (through c-MYC and CyclinD1), invasion (MMP-9 secretion and EMT induction) and angiogenesis (through VEGF), and its function in HNSCC has been extensively documented [185]. The gene discussed is SOAT1; the disease is head and neck squamous cell carcinoma.