ZUP1 and neurodegenerative disease: The mechanisms of SCA7 and SCA3 are still being deciphered, but in these and in other neurodegenerative diseases it appears that DUB misfunction leads to a series of complex downstream events which can derail important ubiquitin-dependent quality control such as macroautophagy—the intracellular degradation of proteins and organelles [68,69].