Furthermore, the use of INCB001158 (a specific inhibitor of this enzyme) was associated with a diminution in the myeloid cell-mediated immunosuppression on T lymphocytes in an in vitro model [84] (Figure 2); its administration alone or associated with chemotherapy, adoptive cell transfers, or ICI induced an increased infiltration of CD8+ and NK cells within tumors, with a restoration of the secretion of proinflammatory cytokines, thus leading to an inhibition of tumor growth in murine cancer models [84]. This evidence concerns the gene CD8A and neoplasm.