Additionally, the top seven nodes of the “Acidosis” network (Figure 4) were present among the top ten nodes of “Acidosis and Bone metastasis” (Figure 5): COL1A1, COL3A1, COL4A1, COL4A2, ITGB3, THBS2, and ITGA11. This evidence concerns the gene ITGB3 and Acidosis.