They are categorized into seven families based on their structures/domains: the ubiquitin-specific proteases (USPs), the ovarian tumor proteases (OTUs), the JAB1/MPN/MOV34 metalloproteases (JAMMs), the ubiquitin C-terminal hydrolases (UCHs), the Josephins, the motif interacting with ubiquitin (MIU)-containing novel DUB family (MINDYs), and ZUP1 [38]. Here, ZUP1 is linked to neoplasm.