Additionally, in breast cancer, high mRNA and protein ISG15 expression are associated with lymphovascular invasion (LVI), higher histological grade, larger tumor size, hormonal receptor negativity, HER2 positivity, HER2-enriched breast cancer subtypes, immune markers (CD8, FOXP3, and CD68), and with poor patient outcome [152]. The gene discussed is ISG15; the disease is breast carcinoma.