Here, even using a mild model of ALI (by instillation of 1 μg LPS) we have observed an exacerbation of LPS-induced pneumonia in the absence of GILZ, characterized by increased neutrophilic infiltration, pro-inflammatory cytokines and neutrophil active chemokines in the airways, and pronounced pulmonary damage. The gene discussed is TSC22D3; the disease is acute respiratory distress syndrome.