TSC22D3 and Sepsis: It has been demonstrated that over-expression of GILZ or administration of TAT-GILZ (a cell permeable GILZ-fusion protein) promoted anti-inflammatory and proresolving actions, by increasing apoptosis of neutrophils and shortening resolution intervals [16], by modulating macrophage polarization and apoptotic cell clearance by efferocytosis [13] and by enhancing bacterial clearance in a model of polymicrobial sepsis [17,18].